- Brother of singer-actress Monica Lewis and concert pianist Barbara Lewis. Their mother sang with the Chicago Opera and their father was a noted classical conductor and pianist.
- Uncle of Rocky Lang and Michael Lang.
- Brother-in-law of Jennings Lang.
- When Marlo Lewis' contract as a producer on the Ed Sullivan Show expired in 1960, he announced he would be leaving the show as producer. In his book, Prime Time by Marlo Lewis, Lewis stated. that "I was tired after twelve years of a marathon run and wanted to work at my own pace, away from network pressures." The show's Associate Producer and Peabody Award-winning director, Bob Precht, took the helm as Producer when Lewis retired.
- He was the son of Jessie H. (Lewis), a singer, and Abe Leon Bloom, a symphonic composer and pianist. His father was born in Missouri and his mother was born in New York, both of them to Russian Jewish parents.
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