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- CreatorBill LawrenceStarsZach BraffDonald FaisonSarah ChalkeIn the unreal world of Sacred Heart Hospital, intern John "J.D." Dorian learns the ways of medicine, friendship and life.
- CreatorDavid CraneMarta KauffmanStarsJennifer AnistonCourteney CoxLisa KudrowFollows the personal and professional lives of six twenty to thirty year-old friends living in the Manhattan borough of New York City.
- CreatorLee AronsohnChuck LorreStarsJon CryerAshton KutcherAngus T. JonesA hedonistic jingle writer's free-wheeling life comes to an abrupt halt when his brother and 10-year-old nephew move into his beach-front house.
- CreatorChuck LorreBill PradyStarsJohnny GaleckiJim ParsonsKaley CuocoA woman who moves into an apartment across the hall from two brilliant but socially awkward physicists shows them how little they know about life outside of the laboratory.
- CreatorAllison M. GibsonStarsReba McEntireJoAnna Garcia SwisherSteve HoweyReba McEntire stars as the titular character in this smash sitcom about a single mom of three, navigating life in a Houston suburb.
- CreatorClaudia LonowStarsJenna ElfmanJon FosterAshley Jensen37-year-old Billie breaks up with her boss at the newspaper and gets pregnant by 22-year-old Zack, who moves into her apartment. They both have their pals.
- CreatorEd YeagerStarsJay MohrPaula MarshallRyan MalgariniNewly divorced after fifteen years of marriage, Gary Brooks, a painting contractor, strives to balance work, shared custody of his two children, a controlling ex-wife, and his foxy new girlfriend.
- CreatorTracy NewmanJonathan StarkStarsJim BelushiCourtney Thorne-SmithLarry Joe CampbellA television show centered around a macho everyman, his loving wife, and their three precocious children.
- CreatorShonda RhimesMichelle LirtzmanStarsEllen PompeoChandra WilsonJames Pickens Jr.A drama centered on the personal and professional lives of five surgical interns and their supervisors.
- CreatorShonda RhimesStarsKate WalshPaul AdelsteinKaDee StricklandA spin-off of the medical drama "Grey's Anatomy" centering on the life of neonatal surgeon Addison Montgomery.
- CreatorRob McElhenneyGlenn HowertonStarsCharlie DayGlenn HowertonRob McElhenneyFive friends with big egos and small brains are the proprietors of an Irish pub in Philadelphia.
- CreatorTom HertzStarsPatrick WarburtonMegyn PriceOliver HudsonTwo couples and their single friend, all at different stages in their relationships, deal with the complications of dating, commitment, and marriage.
- CreatorJames BergStan ZimmermanStarsNicole SullivanRichard RuccoloTisha CampbellA frazzled working mother starts a garage band with her neighbor and a female postal worker.
- CreatorDanny JacobsonKenny SchwartzRick WienerStarsTraylor HowardRyan ReynoldsRichard RuccoloThree twenty-somethings share a Boston apartment and hang around (and work) at a pizza place.
- CreatorFernando GaitánSilvio HortaStarsAmerica FerreraEric MabiusTony PlanaSmart but wholesome Betty embraces her unique appearance and independent attitude in the cutthroat world of New York fashion.
- CreatorJoanna JohnsonStarsFaith FordKelly RipaMacey CruthirdThey're sisters, but blood may be the only thing they have in common. When Faith, a soap opera diva, is killed off her show, "The Sacred and the Sinful," she flees the tabloids by moving to the suburbs with her sister, Hope's, family.
- CreatorJosh H. EttingDavid GarrettJamie KennedyStarsFran DrescherRyan McPartlinMisti TrayaA mother of two ends up falling in love with a man half her age and tries to make him part of the family.
- CreatorDavid E. KelleyStarsCalista FlockhartGreg GermannJane KrakowskiFollows the personal and professional life of lawyer Ally.
- CreatorDavid E. KelleyStarsJames SpaderWilliam ShatnerCandice BergenBoston Legal is a spin-off of the long-running David E. Kelley series The Practice (1997), following the exploits of former Practice character Alan Shore (James Spader) at the legal firm of Crane, Poole, and Schmidt.
- CreatorDavid CroftJeremy LloydStarsGorden KayeCarmen SilveraVicki MichelleIn France during World War II, René Artois runs a small café where Resistance fighters, Gestapo men, German Army officers and escaped Allied POWs interact daily, ignorant of one another's true identity or presence, exasperating René.
- CreatorTracy GambleStarsKatey SagalKaley CuocoAmy DavidsonThe Hennessy clan -- mother Cate, daughters Bridget and Kerry, and son Rory -- look to one another for guidance and support after the death of Paul, the family patriarch. Cate's parents lend a hand.
- CreatorKevin BiegelBill LawrenceStarsCourteney CoxChrista MillerBusy PhilippsFollows the escapades and relationships of a group of neighbors living in Gulfhaven, Florida.
- CreatorMarc CherryStarsTeri HatcherFelicity HuffmanMarcia CrossSecrets and truths unfold through the lives of female friends in one suburban neighborhood after the mysterious suicide of a neighbor.
- CreatorChuck LorreDottie Dartland ZicklinStarsJenna ElfmanThomas GibsonJoel MurrayA free-spirited yoga instructor finds true love in a conservative lawyer and they get married on the first date. Though they are polar opposites, he fulfills her need of stability and she fulfills his need of optimism.
- CreatorDoug EllinStarsKevin ConnollyAdrian GrenierKevin DillonFilm star, Vince Chase, navigates the vapid terrain of Los Angeles with a close circle of friends and his trusty agent.