While Andy's mother is admitted to a psychiatric hospital, the young boy is placed in foster care, and Chucky, determined to claim Andy's soul, is not far behind.
After her mother's mysterious death, Nica begins to suspect that the talking, red-haired doll her visiting niece has been playing with may be the key to recent bloodshed and chaos.
Chucky and Tiffany are resurrected by their innocent gender-confused child, Glen/Glenda, and hit Hollywood, where a movie depicting the killer dolls' murder spree is underway.