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- CreatorStephanie SavageJosh SchwartzStarsBlake LivelyLeighton MeesterPenn BadgleyPrivileged teens living on the Upper East Side of New York can hide no secret from the ruthless blogger who is always watching.
- CreatorMark SchwahnStarsChad Michael MurrayJames LaffertyHilarie Burton MorganHalf-brothers Lucas and Nathan Scott trade between kinship and rivalry both on the basketball court and in the hearts of their friends in the small, but not so quiet town of Tree Hill, North Carolina.
- CreatorShonda RhimesStarsKate WalshPaul AdelsteinKaDee StricklandA spin-off of the medical drama "Grey's Anatomy" centering on the life of neonatal surgeon Addison Montgomery.
- CreatorDavid CraneMarta KauffmanStarsJennifer AnistonCourteney CoxLisa KudrowFollows the personal and professional lives of six twenty to thirty year-old friends living in the Manhattan borough of New York City.
- CreatorDarren StarJeff JudahGabe SachsStarsShenae Grimes-BeechTristan Mack WildsAnnaLynne McCordA Kansas family relocates to Beverly Hills, where their two children adapt to the infamous social drama of West Beverly Hills High.
- CreatorEileen HeislerDeAnn HelineStarsPatricia HeatonNeil FlynnCharlie McDermottThe daily mishaps of a married woman and her semi-dysfunctional family and their attempts to survive life in general in the town of Orson, Indiana.
- CreatorGregory Thomas GarciaStarsLucas NeffMartha PlimptonGarret DillahuntJimmy becomes a single parent to an infant after her mother, with whom he had a one-night stand, ends up on Death Row.
- CreatorMark BrazillBonnie TurnerTerry TurnerStarsTopher GraceLaura PreponMila KunisA comedy revolving around a group of teenage friends, their mishaps, and their coming of age, set in 1970s Wisconsin.
- CreatorJana SinyorStarsErin KarplukReagan PasternakMichael Riley"Therapist" Dr. Tom - who is constantly spouting famous and not so famous historical quotes - is Erica Strange's savior and worst enemy.
- CreatorKevin BiegelBill LawrenceStarsCourteney CoxChrista MillerBusy PhilippsFollows the escapades and relationships of a group of neighbors living in Gulfhaven, Florida.
- CreatorAlex BarnowMarc FirekMatthew PerryStarsMatthew PerryAndrea AndersJames LesureBen Donovan manages The Sunshine Centre, a second-rate sports arena in San Diego.
- CreatorJon Robin BaitzStarsDave AnnableCalista FlockhartRachel GriffithsThe story of the drama surrounding a family's adult siblings.
- CreatorJames L. BrooksMatt GroeningSam SimonStarsDan CastellanetaNancy CartwrightHarry ShearerThe satiric half-hour adventures of a working-class family in the misfit city of Springfield.
- CreatorDavid CaspeStarsEliza CoupeElisha CuthbertZachary KnightonThis Chicago-set sitcom follows the intertwined lives of six young urbanites trying to learn the ropes of adulthood. Through breakups and whatever other curve-balls life throws them, the pals stick together.
- CreatorMichele AbbottIlene ChaikenKathy GreenbergStarsJennifer BealsLeisha HaileyLaurel HollomanFollows the lives and loves of a small, close-knit group of lesbian women living in Los Angeles as well as the friends and family members that either support or loathe them.
- CreatorDarren StarStarsSarah Jessica ParkerKim CattrallKristin DavisFour female New Yorkers gossip about their sex lives (or lack thereof) and find new ways to deal with being a woman in the late 1990s.
- CreatorMarc CherryStarsTeri HatcherFelicity HuffmanMarcia CrossSecrets and truths unfold through the lives of female friends in one suburban neighborhood after the mysterious suicide of a neighbor.
- CreatorSteven LevitanChristopher LloydStarsEd O'NeillSofía VergaraJulie BowenThree different, but related, families face trials and tribulations in their own uniquely comedic ways.
- CreatorElizabeth MeriwetherStarsZooey DeschanelJake JohnsonMax GreenfieldAfter a bad break-up, Jess, an offbeat young woman, moves into an apartment loft with three single men. Although they find her behavior very unusual, the men support her - most of the time.
- CreatorLiz BrixiusEvan DunskyLinda WallemStarsEdie FalcoMerritt WeverPaul SchulzeA drug-addicted nurse struggles to find a balance between the demands of her frenetic job at a New York City hospital and an array of personal dramas.
- CreatorAmy BrennemanBill D'EliaBarbara HallStarsAmy BrennemanTyne DalyKarle WarrenA family drama focused on three generations of women living together in Hartford, Connecticut.
- CreatorLee AronsohnChuck LorreStarsJon CryerAshton KutcherAngus T. JonesA hedonistic jingle writer's free-wheeling life comes to an abrupt halt when his brother and 10-year-old nephew move into his beach-front house.
- CreatorShane BrennanStarsChris O'DonnellDaniela RuahLL Cool JNCIS's covert operations team go undercover to investigate cases involving terrorism and National Security.
- CreatorTom KapinosStarsDavid DuchovnyNatascha McElhoneEvan HandlerA writer tries to juggle his career, his relationship with his daughter and his ex-girlfriend, as well as his appetite for beautiful women.
- CreatorJosh SchwartzStarsMischa BartonAdam BrodyPeter GallagherA troubled youth becomes embroiled in the lives of a close-knit group of people in the wealthy, upper-class neighborhood of Newport Beach, Orange County, California.
- StarsFernando LuísRita BlancoRicardo CarriçoThe life of a doctor within his work and his family.
- CreatorAaron SorkinStarsJeff DanielsEmily MortimerJohn Gallagher Jr.A newsroom undergoes some changes in its workings and morals as a new team is brought in, bringing unexpected results for its existing news anchor.
- CreatorMike KelleyStarsMadeleine StoweEmily VanCampGabriel MannAn emotionally troubled young woman sets out to exact revenge against the people who wronged her father.
- CreatorLauren IungerichStarsAshley RickardsBeau MirchoffJillian Rose ReedAn unpopular 15-year-old gains immediate, yet unwanted, popularity at her high school when the student body mistakes an accident she has for a suicide attempt.
- CreatorScott SilveriStarsMatthew PerryLaura BenantiJulie WhitePressured by his boss to join a support group because he can't move forward after his wife's death, an irreverent sportscaster finds connection with the extremely varied members.
- CreatorJoão Emanuel CarneiroStarsAdriana EstevesDébora FalabellaMurilo BenícioA young girl who had her life ruined by an ambitious, unscrupulous woman returns to her as an adult, under a new identity and seeking revenge.
- CreatorSeth MacFarlaneDavid ZuckermanStarsAlex BorsteinSeth MacFarlaneSeth GreenIn a wacky Rhode Island town, a dysfunctional family strives to cope with everyday life as they are thrown from one crazy scenario to another.
- CreatorShonda RhimesStarsKerry WashingtonDarby StanchfieldKatie LowesA former White House Communications Director starts her own crisis management firm only to realize her clients are not the only ones with secrets.