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- CreatorSeth MacFarlaneDavid ZuckermanStarsAlex BorsteinSeth MacFarlaneSeth GreenIn a wacky Rhode Island town, a dysfunctional family strives to cope with everyday life as they are thrown from one crazy scenario to another.
- CreatorDavid X. CohenMatt GroeningStarsBilly WestJohn DiMaggioKatey SagalPhilip J. Fry, a pizza delivery boy, is accidentally frozen in 1999 and thawed out on New Year's Eve 2999.
- CreatorMike BarkerSeth MacFarlaneMatt WeitzmanStarsSeth MacFarlaneWendy SchaalScott GrimesThe escapades of Stan Smith, a conservative C.I.A. Agent dealing with family life, and keeping America safe.
- CreatorRichard AppelMike HenrySeth MacFarlaneStarsMike HenrySanaa LathanKevin Michael RichardsonCleveland Brown moves back to his hometown in Virginia, where he finds his high school sweetheart and her two troublemaking kids.
- CreatorJosh BermanStarsBrooke ElliottMargaret ChoKate LeveringA vapid aspiring model killed in a car crash gets brought back to life as an intelligent, overweight lawyer, hoping to find the meaning of inner beauty.
- CreatorTina FeyStarsTina FeyAlec BaldwinTracy MorganLiz Lemon, head writer of the sketch-comedy show "TGS with Tracy Jordan", must deal with an arrogant new boss and a crazy new star while trying to run a successful television show without losing her mind.
- StarsGordon RamsayJean Philippe SusilovicScott LeibfriedWorld renowned chef Gordon Ramsay puts aspiring young chefs through rigorous cooking challenges and dinner services at his restaurant in Hollywood, "Hell's Kitchen".
- CreatorJana SinyorStarsErin KarplukReagan PasternakMichael Riley"Therapist" Dr. Tom - who is constantly spouting famous and not so famous historical quotes - is Erica Strange's savior and worst enemy.
- CreatorCarter BaysCraig ThomasStarsJosh RadnorJason SegelCobie SmuldersA father recounts to his children - through a series of flashbacks - the journey he and his four best friends took leading up to him meeting their mother.
- CreatorLee AronsohnChuck LorreStarsJon CryerAshton KutcherAngus T. JonesA hedonistic jingle writer's free-wheeling life comes to an abrupt halt when his brother and 10-year-old nephew move into his beach-front house.
- CreatorDan HarmonStarsJoel McHaleDanny PudiDonald GloverA suspended lawyer is forced to enroll in a community college with an eccentric staff and student body.
- CreatorTom HertzStarsPatrick WarburtonMegyn PriceOliver HudsonTwo couples and their single friend, all at different stages in their relationships, deal with the complications of dating, commitment, and marriage.
- CreatorChuck LorreBill PradyStarsJohnny GaleckiJim ParsonsKaley CuocoA woman who moves into an apartment across the hall from two brilliant but socially awkward physicists shows them how little they know about life outside of the laboratory.
- CreatorIan BrennanBrad FalchukRyan MurphyStarsLea MicheleJane LynchMatthew MorrisonA group of ambitious misfits try to escape the harsh realities of high school by joining a glee club headed by a passionate Spanish teacher.
- CreatorJason KatimsStarsPeter KrauseLauren GrahamDax ShepardThe lives and tragedies of the Braverman family tree.
- CreatorGregory Thomas GarciaStarsLucas NeffMartha PlimptonGarret DillahuntJimmy becomes a single parent to an infant after her mother, with whom he had a one-night stand, ends up on Death Row.
- CreatorChris FedakJosh SchwartzStarsZachary LeviYvonne StrahovskiJoshua GomezWhen a computer geek inadvertently downloads critical government secrets into his brain, both the CIA and the NSA assign an agent to protect him and exploit his newfound skills.
- CreatorDavid CaspeStarsEliza CoupeElisha CuthbertZachary KnightonThis Chicago-set sitcom follows the intertwined lives of six young urbanites trying to learn the ropes of adulthood. Through breakups and whatever other curve-balls life throws them, the pals stick together.
- CreatorSteven LevitanChristopher LloydStarsEd O'NeillSofía VergaraJulie BowenThree different, but related, families face trials and tribulations in their own uniquely comedic ways.
- CreatorBonnie ZacherleStarsSherry LynnBettina BushSusan BluThe story of a human named Megan in a world of magical ponies and their adventures together in Pony Land.
- CreatorLauren FaustBonnie ZacherleStarsAshleigh BallTara StrongTabitha St. GermainAfter learning that her friends, as well as herself, are the magical Elements of Harmony, studious unicorn Twilight Sparkle is sent by her mentor, Princess Celestia, to Ponyville to study the magic of friendship with help from her friends.
- CreatorTrey ParkerMatt StoneBrian GradenStarsTrey ParkerMatt StoneIsaac HayesFollows the misadventures of four irreverent grade-schoolers in the quiet, dysfunctional town of South Park, Colorado.
- CreatorElizabeth MeriwetherStarsZooey DeschanelJake JohnsonMax GreenfieldAfter a bad break-up, Jess, an offbeat young woman, moves into an apartment loft with three single men. Although they find her behavior very unusual, the men support her - most of the time.
- CreatorEileen HeislerDeAnn HelineStarsPatricia HeatonNeil FlynnCharlie McDermottThe daily mishaps of a married woman and her semi-dysfunctional family and their attempts to survive life in general in the town of Orson, Indiana.
- CreatorKenneth JohnsonScott PetersStarsElizabeth MitchellMorris ChestnutJoel GretschAn extraterrestrial race arrives on Earth with seemingly good intentions, only to slowly reveal their true machinations the more ingrained into society they become.