This is the second time that Patrick Muldoon has played a character who has to fight off giant spiders, the first time being in Ice Spiders (2007)
This is the third movie in the Spiders film series, starting with "Spiders (2000)", then continuing with "Spiders II: Breeding Ground (2002)".
Patrick Muldoon, Christa Campbell and William Hope all acted in other monster movies. Muldoon was cast as Zander Barcalow in "Starship Troopers" and as Dan Dashiell in "Ice Spiders". Campbell played Liz in "Mosquitoman", and Hope portrayed Lieutenant Gorman in "Aliens". Director Tibor Takacs also worked on "Ice Spiders" and "Mosquitoman".