The children of star Julianne Moore and writer/director Bart Freundlich make their movie debuts in "Trust the Man". Caleb Freundlich plays Cosmos, Pamela's son who punches David Duchovny and Liv Freundlich plays Moore's daughter Maggie in the final scenes.
Billy Crudup and Moore started in 'World Travelers' together (2001)
Duchovny and Moore worked in Evolution together.
Claudia Lopez's debut.