One of the scriptwriters is called Elliot Hope, the same name as the fictional character, played by Paul Bradley, in the series.
Following the death of Laura Sadler who played Sandy Harper, the scriptwriters consulted her mother, Sonja Sadler, to find the most fitting way to write out the much-loved character and actress from the series. Mrs Sadler devised the storyline in which Sandy wins the lottery and secretly leaves the hospital to make a new life for herself in Australia, leaving money for her friends.
Holby City is filmed in what used to be a BBC office at Elstree Studios: Top of the Pops staff were moved out and hospital wards were brought in.
On 2 June 2021 it was announced on the BBC News website that production of Holby City would end, with the final season being shown in March 2022.
Jac Naylor was voted "One of Holby City's most hated characters".