- He auditioned for the role of Tom Cooper in Interstellar (2014) but lost to his Lady Bird (2017) co-star Timothée Chalamet.
- With his Best Supporting Actor nomination for Manchester by the Sea (2016), he became the first male aged 25 or under to have received an Academy Award nomination for acting since Jake Gyllenhaal for Brokeback Mountain (2005) (age at the time of nomination).
- Son of Susan Bruce (Titman), a poet, and Peter Hedges (Peter Simpson Hedges), a writer, director, novelist, and playwright.
- As of 2018, he has appeared in four films that were nominated for the Best Picture Oscar: The Grand Budapest Hotel (2014), Manchester by the Sea (2016), Lady Bird (2017) and Three Billboards Outside Ebbing, Missouri (2017).
- Asked his Manchester by the Sea (2016) co-star Anna Baryshnikov to prom but was turned down by her because she was 22 at that time.
- Nominated for the 2019 Golden Globe Award in the Best Performance by an Actor in a Motion Picture - Drama category for his role as Jared Eamons in Boy Erased (2018), but lost to Rami Malek for Bohemian Rhapsody (2018).
- Hedges and Dev Patel are the first males born in the 1990s to have received Academy Award nominations for acting (both were nominated for Best Supporting Actor for 2016 films, Hedges for Manchester by the Sea (2016) and Patel for Lion (2016)). Keisha Castle-Hughes is the first person born in the decade to have been nominated for an acting Oscar (for Whale Rider (2002), receiving a Best Actress nomination for 2003's movie year). Timothée Chalamet is the first person born in the decade to be nominated for Best Actor, for Call Me by Your Name (2017).
- Lucas was nominated for an Oscar for his role in Manchester by the Sea (2016), 14 years after his father, Peter Hedges, was nominated for an Oscar for the screenplay for About a Boy (2002).
- Has a family background in both the arts and religion. Aside from his artistic parents, his maternal grandfather, John DeWitt Titman, Jr., was a vice president at HBO New York, and his maternal grandmother Narcissa is a theatre director, lecturer, and choir director. His paternal grandfather, The Rev. Robert Boyden Hedges, was an Episcopalian minister, and his maternal great-grandfather, The Rev. Dr. V. Carney Hargroves, was president of the Baptist World Alliance.
- Is of English, as well as some German, Scots-Irish/Northern Irish, and Scottish, descent.
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