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- An invisible and mysterious force field descends upon the small town of Chester's Mill, Maine, USA, trapping residents inside, cut off from the rest of civilization. The trapped townspeople must discover the secrets and purpose of the "dome" or "sphere" and its origins, while coming to learn more than they ever knew about each other and animals too.
- Centers on an ultra-competitive surgeon whose life is changed forever when his ex-wife dies and begins teaching him what life is all about from the here-after.
- "THE LIGHT," IS A SPECIAL GLOBAL VIDEO TRIBUTE TO MEMORIALIZE THE ORLANDO PULSE NIGHTCLUB VICTIMS Created by Shawn Balentine, Hollywood's Openly Gay, Out Stuntman/Stunt Coordinator.
- After the ghost of Michael's ex-wife visits him from the afterlife and asks him to help continue running her low income clinic, he finds himself rushing back and forth between taking care of his own patients at Holt Neuro and her less fortunate patients at the clinic.
- While interviewing doctors to run the clinic, Michael helps a man who passed out, but refuses care due to lack of insurance. Meanwhile, as Michael evaluates a woman, he notices lesions on her brain that require immediate surgery, even as he doesn't know the exact diagnosis.
- Michael and Kate are forced to work together to try and save a patient with a deadly virus. Meanwhile, at Holt Neuro, as Michael treats a nervous bride-to-be who is experiencing headaches, he notices her mother is exhibiting symptoms of a serious condition.
- While at the clinic, Michael runs into a former football star that he performed successful surgery on years ago, and is now a shell of his former self, living on the streets. At Holt Neuro, Michael examines a patient who suffers from post-traumatic stress disorder.
- Michael works double duty trying to save a pregnant personal friend he recently diagnosed with a brain tumor and a little boy with sickle cell disease.
- Michael must decide if it is worth risking his practice to save a patient's life. Meanwhile, he courts Evan "E-Mo" Morris, a neuropsychiatrist to join his practice after E-Mo determines a patient's diagnosis by reading her body language.
- When Michael treats a patient who is hearing voices, he turns to Anton for help. Meanwhile, Kate's first day at the clinic doesn't go well.
- When Michael finds out a patient with a malignant brain tumor committed a horrible crime, he struggles with whether to save the man's life. Meanwhile, a female firefighter who appears to be disoriented is brought to Holt Neuro for evaluation.
- While tending to patients at the clinic during a blizzard, Michael shows signs of a severe condition that requires immediate surgery.
- Dr. Barnes and Dr. Sykora save a man on a bus who turns out to have a DNR order. Meanwhile, Rita's son has a motorcycle accident that reveals an existing medical condition.
- Michael and E-Mo disagree about how to treat a patient with a brain tumor. Meanwhile, a teenage girl gives birth at the clinic and immediately runs out, leaving the baby behind.
- Michael saves a man from drowning and learns his identity is a mystery.
- When a spoiled pop star comes to Holt Neuro experiencing unusual symptoms, and a young girl at the Clinica exhibits similar symptoms on the same day, it forces both teams of doctors to try and piece together their common link.
- When Michael's high school sweetheart comes to Holt Neuro with an irreversible condition, he will stop at nothing to try and save her, until Anna intervenes. Meanwhile, Zeke deals with the news that his best friend's cancer has returned.
- A distraught woman takes the Clinica staff hostage after Michael testifies for a former patient who he believed suffered uncontrollable urges due to a brain tumor.
- Michael learns that a patient at the clinic has a special connection to Anna. (Frances Fisher guest stars)
- In Chester's Mill, Maine, a strange occurrence locks the town in under an invisible dome-like surface.
- Following Duke's death, his house catches fire, forcing the town to rally together to form a bucket brigade. Elsewhere, Junior ambushes Barbie, while Dodee and Phil pick up a military frequency.
- After a Deputy is killed, Big Jim organizes a search party to hunt down the culprit. Meanwhile, Joe and Norrie continue to experience strange seizures.
- The town suffers from an outbreak of meningitis. Julia learns that Phil and Barbie are connected to her missing husband. Angie struggles to escape the bomb shelter.
- When friends and family from outside the dome come to visit, Barbie learns the military plan to destroy the dome with a missile.
- After Julia and Dodee speculate that the source of the radio signal jam could be the answer to the dome's origin, they are led to Joe and Norrie. Meanwhile, Angie seeks help after escaping from Junior.