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- Using a crack team of doctors and his wits, an antisocial maverick doctor specializing in diagnostic medicine does whatever it takes to solve puzzling cases that come his way.
- The series follows Adrian Monk, a brilliant former San Francisco detective, who now consults the police as a private consultant whilst battling with an obsessive-compulsive disorder.
- House treats a patient on death row while Dr. Cameron avoids telling a patient she has a terminal illness.
- While House and his team scramble to discover what's causing brain and kidney dysfunction in a pregnant woman, Vogler is on the warpath to get House fired.
- The team takes care of a student with inexplicable electrical shocks, and House's parents visit.
- A nun suffering from acute dermatitis and asthma treated by House with possibly the wrong medication comes dangerously close to death.
- When a famous writer is brought in with language difficulties, House must assist via phone while waiting for a delayed plane.
- A woman comes down with symptoms of African sleeping sickness, but there seems to be no way she could have contracted it. House and his aides must ask a few tough questions and make some tough decisions in order to try to save her.
- A patient with 40% body burns and inexplicable cardiac and neurological signs is treated by the team, while House pursues disproving an old enemy's medical study.
- A morbidly obese ten-year-old girl has a heart attack, and her mother insists that House and his team look past her weight to find the diagnosis. Meanwhile, Vogler pressures House to fire a member of his staff. Clinic Patients: Unidentified man with an infected pierced scrotum; overweight woman with a 30-pound tumor on her ovaries who refuses to have it removed, because she worries she will be unattractive.
- Cuddy joins the team after her handyman falls off of her roof and begins to develop bizarre symptoms. Clinic Cases: African American man who objects to "minority meds."
- House has to deal with his promised dinner date with Cameron, a mysterious stroke in a clinic patient and a libidinous senior citizen.
- House and the team must determine what is causing an increasingly deceitful patient's muscle flailing. Stacy makes a decision, and Cameron avoids a test.
- A college boy whose low blood pressure does not respond with IV fluids piques House's curiosity. Clinic Cases: A woman who had a cold last week, man with a sore throat, woman whose leg hurts after running 6 miles, a boy and his MP3 Player.
- An ambitious and charismatic Black senator campaigning for the presidency falls ill from a mysterious malady, possibly AIDS.
- A detoxed sports star about to make his comeback breaks his arm due to brittle bones. Clinic Cases: Woman with leg pain, man trying to remove his contact lenses, a dentist with various issues, and a hung over teenager - all in 70 seconds.
- A doctor campaigns against the epidemic of TB in Africa, possibly at the risk of his own life.
- Chaos ensues after Chase's negligence leads to the death of a female patient. Now, after an inquiry from the hospital board, and a subpoena from the patient's brother, it's up to Stacey to protect Chase's career, as well as House's.
- A 38-year-old mother, apparently suffering from thrombosis, alcoholism and schizophrenia, has only her young son as caregiver.
- House's ex Stacy Warner asks him to treat her husband. House takes over a diagnostics class for a day and presents the class with three case studies of leg pain. As House tells his story and the class gradually fills up with listeners, the class learns a lot about how to be better doctors, and Chase, Foreman and Cameron learn some important details of House's past.
- Monk is called to a crime scene where a pet seems to be the killer: Ian Blackburn is found in his the panic room, shot four times and his pet chimp holding the weapon. Did the chimp do it?
- Cameron gets mad at Foreman because Foreman steals his idea for an article. The case of the week: a lesbian woman has not slept for ten days despite taking a bottle of sleeping pills.
- A police officer in critical condition has bizarre symptoms, and Dr. Foreman finds himself in an unpleasant situation.
- House takes on a teenage faith healer, Wilson desperately wants into a poker game, and tensions escalate between Cameron and Foreman.
- House cares for a young Katrina victim, the alleged daughter of an old friend of his. He supposes she has hallucinations because of the heart, but it turns out not to be the cause. House discovers a disease that her grandfather had.
- House tries radical procedures to save Foreman's life; Foreman's father visits.