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- Using a crack team of doctors and his wits, an antisocial maverick doctor specializing in diagnostic medicine does whatever it takes to solve puzzling cases that come his way.
- New Jersey mob boss Tony Soprano deals with personal and professional issues in his home and business life that affect his mental state, leading him to seek professional psychiatric counseling.
- Five friends with big egos and small brains are the proprietors of an Irish pub in Philadelphia.
- A white-collar criminal agrees to help the FBI catch other white-collar criminals using his expertise as an art and securities thief, counterfeiter, and conman.
- The Baltimore drug scene, as seen through the eyes of drug dealers and law enforcement.
- When a psychopath commits murders based on novelist Castle's books, Detective Beckett seeks his help to solve the case. He decides to work with her and uses his experiences as research for his novels.
- The doctors who work in the ER at the County General Hospital in Chicago grapple with ups and downs in their personal and professional lives while trying to give apt medical care to their patients.
- The absurd antics of an Indiana town's public officials as they pursue sundry projects to make their city a better place.
- Alicia Florrick has been a good wife to her husband, a former state's attorney. After a very humiliating sex and corruption scandal, he is behind bars. She must now provide for her family and returns to work as a litigator in a law firm.
- A family struggles for survival in a world where most humans have been killed by blind but noise-sensitive creatures. They are forced to communicate in sign language to keep the creatures at bay.
- The drug-induced utopias of four Coney Island people are shattered when their addictions run deep..
- An Atlantic City politician plays both sides of the law by conspiring with gangsters during the Prohibition era.
- An F.B.I. agent is forced to work with an institutionalized scientist and his son in order to rationalize a brewing storm of unexplained phenomena.
- A drama that follows the lives of the Dillon Panthers, one of the nation's best high school football teams, and their head coach Eric Taylor.
- Teddy Daniels and Chuck Aule, two US marshals, are sent to an asylum on a remote island in order to investigate the disappearance of a patient, where Teddy uncovers a shocking truth about the place.
- Security guard David Dunn uses his supernatural abilities to track Kevin Wendell Crumb, a disturbed man who has twenty-four personalities.
- Film star, Vince Chase, navigates the vapid terrain of Los Angeles with a close circle of friends and his trusty agent.
- The Philadelphia homicide squad's lone female detective finds her calling when she's assigned "cold cases," older crimes that have never been solved.
- An unfairly discredited but brilliant ER doctor winds up working with his younger brother in the Hamptons as a concierge doctor to the uber-rich and ultra-elite.
- Nina is a talented but unstable ballerina on the verge of stardom. Pushed to the breaking point by her artistic director and a seductive rival, Nina's grip on reality slips, plunging her into a waking nightmare.
- In 1990s Pittsburgh, a medicine peddler starts a relationship with a young woman suffering from Parkinson's disease.
- Two men and their sons must deal with the unforeseen consequences of their actions.
- After their high school basketball coach passes away, five good friends and former teammates reunite for a Fourth of July holiday weekend.
- The lives of two lovelorn spouses from separate marriages, a registered sex offender, and a disgraced ex-police officer intersect as they struggle to resist their vulnerabilities and temptations in suburban Massachusetts.
- Liz Lemon, head writer of the sketch-comedy show "TGS with Tracy Jordan", must deal with an arrogant new boss and a crazy new star while trying to run a successful television show without losing her mind.